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Thu, Feb 13, 2020 5:04 AM
利用螺旋式文獻回顧，再回頭看老化議題
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Thu, Feb 13, 2020 5:07 AM
Leonid Peshkin
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Thu, Feb 13, 2020 5:07 AM
Leonid Peshkin - The dynamics of gene expression in ...
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Thu, Feb 13, 2020 5:21 AM
identify genes and processes altered by aging at the transcriptional level with unprecedented power
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Thu, Feb 13, 2020 5:21 AM
reveals previously unknown transcriptional changes during aging
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Thu, Feb 13, 2020 5:22 AM
targets for future studies in helping to define biomarkers of aging
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Thu, Feb 13, 2020 5:23 AM
testing their mechanistic role experimentally
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Thu, Feb 13, 2020 5:23 AM
these molecular signatures of aging not only reflect a mix of degenerative processes but also transcriptional responses to aging as healthy cells adapt to degeneration
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Thu, Feb 13, 2020 5:24 AM
aging transcriptome
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Thu, Feb 13, 2020 5:48 AM
想法開始發散了
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Thu, Feb 13, 2020 5:49 AM
circRNA的穩定性，可能與其對老化疾病的影響有關
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Thu, Feb 13, 2020 5:52 AM
藉由結合circRNA的flanking intron，QKI蛋白可以促進circRNA的生成
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Thu, Feb 13, 2020 5:55 AM
突變的RMB20蛋白，會促進circRNA的生成
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Thu, Feb 13, 2020 5:55 AM
RBM20, by excluding specific exons from the pre-mRNA, provides the substrate to form this class of RBM20-dependent circRNAs.
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Thu, Feb 13, 2020 5:59 AM
更正：the loss of RBM20 caused only a specific subset of titin circRNAs to be lost.
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Thu, Feb 13, 2020 5:59 AM
These circRNAs originated from the RBM20-regulated I-band region of the titin transcript.
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Thu, Feb 13, 2020 6:04 AM
alternative splicing也是個不錯的議題
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